Cvid and pregnancy, CVID (common variable immune deficiency) is a kind of primary immunodeficiency characterized as immune system malfunction caused by a mutation in one or more genes. More than 400 main immunodeficiencies are recognised by the World Health Organization (WHO), ranging from somewhat frequent to extremely rare. Keep reading to know all details about cvid and pregnancy.
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Cvid and pregnancy
CVID is one of the most common symptomatic primary immunodeficiencies,
A wide range of symptoms and intensity are present. While the syndrome is classified as a genetic disorder,
It is actually a collection of diseases with uncertain etiology.
Low levels of certain proteins (immunoglobulins) in the fluid part of the blood characterize CVID.
As a result, antibodies are lost, and the body’s ability to combat invading germs, poisons, and other foreign substances is harmed.
Specialized white blood cells (B cells) create immunoglobulins when they grow into plasma cells.
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Symptoms and Signs
The symptoms and clinical history of CVID range from moderate to severe.
The immunoglobulins that are affected differently.
Some patients, for example, have deficiencies in all three types of igm: immunoglobulin G (IgG), immunoglobulin A (IgA),
And immunoglobulin M (IgM), whereas others only have deficiencies in IgG and IgA.
The diagnosis is made when functional antibodies are found to be very low or nonexistent.
The onset of symptoms, such as recurrent and uncommon infections, may begin in infancy or adolescence;
However, many individuals do not receive a diagnosis until their third or fourth decade of life.
CVID patients struggle to fight infections due to a lack of antibodies, which are normally produced to fight against invading germs.
Vaccines are ineffective because antibody synthesis is inhibited.
Recurrent bacterial infections are prevalent, especially in the upper and lower respiratory tracts, such as the lungs, sinuses, and ears.
Repeated lung infections can result in chronic lung disease and potentially fatal consequences.
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Causes
For the most part, the cause of CVID is unknown, however in around 20% of cases, a genetic basis has been established.
CVID has reported autosomal dominant (mainly) and autosomal recessive inheritance.
Rare autosomal abnormalities or complicated interplay of environmental, And genetic causes are more likely to create sporadic instances with no clear family history of the condition (multifactorial inheritance).
The majority of the causal genes found are those involved in immune response control,
Hence mutations in genes involved in B cell growth and function are only a minor part of the genes that cause CVID.
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Diagnosis
CVID is identified in most patients after a thorough clinical examination, identification of specific symptoms and physical features,
A complete patient and family history, and laboratory confirmation of a pattern of immune system deficiencies.
The confirmation of certain immunological abnormalities is crucial in determining the diagnosis of CVID.
Low blood (serum) IgG globulin concentrations, ranging from severely decreased (100 mg/dL).
To slightly below the adult normal range (500-1200 mg/dL), are used to diagnose CVID.
That was Cvid and pregnancy.
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Cvid and pregnancy
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